David P Nicolau Selected Research

Daptomycin

1/2021	Efficacy assessment of lysin CF-296 in addition to daptomycin or vancomycin against Staphylococcus aureus in the murine thigh infection model.
1/2020	Development of Daptomycin Susceptibility Breakpoints for Enterococcus faecium and Revision of the Breakpoints for Other Enterococcal Species by the Clinical and Laboratory Standards Institute.
1/2020	Synergistic Activity of Exebacase (CF-301) in Addition to Daptomycin against Staphylococcus aureus in a Neutropenic Murine Thigh Infection Model.
1/2019	Pharmacodynamic Analysis of Daptomycin-treated Enterococcal Bacteremia: It Is Time to Change the Breakpoint.
10/2018	Pharmacodynamics of Daptomycin against Enterococcus faecium and Enterococcus faecalis in the Murine Thigh Infection Model.
1/2014	In vitro pharmacodynamics of human simulated exposures of ceftaroline and daptomycin against MRSA, hVISA, and VISA with and without prior vancomycin exposure.
11/2008	In vivo microdialysis study of the penetration of daptomycin into soft tissues in diabetic versus healthy volunteers.
1/2008	Successful treatment of a neonate with persistent vancomycin-resistant enterococcal bacteremia with a daptomycin-containing regimen.
11/2006	Serum bactericidal activities of high-dose daptomycin with and without coadministration of gentamicin against isolates of Staphylococcus aureus and Enterococcus species.
7/2006	Update on daptomycin: the first approved lipopeptide antibiotic.

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David P Nicolau Research Topics

Disease

201	Infections 06/2022 - 01/2002
51	Pneumonia (Pneumonitis) 01/2022 - 05/2002
34	Body Weight (Weight, Body) 10/2021 - 10/2002
27	Critical Illness (Critically Ill) 07/2022 - 11/2006
15	Bacteremia 01/2022 - 04/2004
15	Intraabdominal Infections 12/2020 - 08/2005
14	Cystic Fibrosis (Mucoviscidosis) 01/2021 - 04/2004
13	Healthcare-Associated Pneumonia 10/2021 - 05/2002
13	Ventilator-Associated Pneumonia 09/2019 - 02/2009
12	Urinary Tract Infections (Urinary Tract Infection) 01/2022 - 01/2015
11	Sepsis (Septicemia) 01/2020 - 07/2005
11	Respiratory Tract Infections (Respiratory Tract Infection) 09/2017 - 02/2004
9	Wounds and Injuries (Trauma) 01/2022 - 11/2008
9	Soft Tissue Infections 05/2021 - 05/2003
8	Blister (Bulla) 11/2015 - 05/2003
7	Diabetic Foot 01/2022 - 01/2010
7	Cross Infection (Nosocomial Infection) 10/2019 - 08/2004
6	Pneumococcal Pneumonia 11/2021 - 05/2002
6	Bacterial Pneumonia 01/2020 - 09/2011
5	Bacterial Infections (Bacterial Infection) 04/2021 - 02/2004
5	Communicable Diseases (Infectious Diseases) 01/2020 - 01/2008
5	Surgical Wound Infection 01/2019 - 08/2009
5	Pseudomonas Infections 01/2018 - 05/2002
4	Wound Infection (Wound Infections) 01/2022 - 01/2005
4	Osteomyelitis 06/2021 - 05/2016
4	Meningitis 12/2020 - 01/2006
4	Peritonitis 05/2007 - 01/2005
3	Endocarditis 01/2022 - 03/2007
3	AIDS-Related Complex (ARC) 04/2021 - 12/2019
3	Overweight 12/2020 - 09/2015
3	Febrile Neutropenia 12/2017 - 10/2012
3	Coinfection 06/2016 - 08/2009
3	Clostridium Infections 04/2016 - 08/2015
3	Superinfection 07/2013 - 02/2009
3	Otitis Media 01/2008 - 01/2007

Drug/Important Bio-Agent (IBA)

92	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 12/2002
50	Pharmaceutical PreparationsIBA 01/2021 - 09/2002
41	Meropenem (Merrem)FDA LinkGeneric 10/2021 - 05/2003
28	Cefepime (Maxipime)FDA LinkGeneric 07/2022 - 06/2004
27	Carbapenems (Carbapenem Antibiotics)IBA 01/2022 - 08/2004
27	Vancomycin FDA LinkGeneric 11/2021 - 11/2006
22	Tazobactam Drug Combination Piperacillin (Zosyn)FDA LinkGeneric 10/2021 - 04/2002
21	tazobactam drug combination ceftolozaneIBA 04/2021 - 09/2015
19	LactamsIBA 01/2022 - 02/2014
16	Tigecycline (Tygacil)FDA Link 09/2019 - 01/2005
14	Ceftazidime (Fortum)FDA LinkGeneric 01/2020 - 06/2004
13	CefiderocolIBA 06/2022 - 11/2017
13	Daptomycin FDA Link 01/2021 - 09/2003
12	Levofloxacin (Levaquin)FDA Link 12/2021 - 04/2004
12	CreatinineIBA 04/2021 - 03/2004
11	Cefazolin (Ancef)FDA LinkGeneric 05/2021 - 02/2012
11	Linezolid (Zyvox)FDA Link 01/2021 - 01/2005
11	Doripenem FDA Link 01/2016 - 07/2008
10	Tazobactam FDA LinkGeneric 12/2021 - 05/2002
9	Ertapenem (Invanz)FDA Link 01/2022 - 01/2005
9	Anti-Infective Agents (Microbicides)IBA 10/2021 - 01/2008
9	ceftazidime drug combination avibactamIBA 01/2020 - 12/2012
9	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 01/2019 - 12/2006
9	beta-LactamsIBA 01/2018 - 01/2005
8	Cephalosporins (Cephalosporin Antibiotics)IBA 01/2022 - 12/2002
8	Imipenem FDA Link 01/2020 - 10/2005
8	avibactamIBA 01/2020 - 07/2011
8	Colistin (Coly-Mycin)FDA Link 09/2019 - 01/2006
8	Ceftaroline FDA Link 12/2014 - 07/2011
7	Amikacin (A.M.K)FDA LinkGeneric 01/2020 - 03/2016
6	ceftolozaneIBA 01/2022 - 05/2016
6	cefepime-zidebactamIBA 12/2021 - 11/2018
6	telavancin FDA Link 11/2021 - 02/2006
6	eravacyclineIBA 12/2020 - 01/2014
6	AminoglycosidesIBA 10/2019 - 01/2006
6	Methicillin (Metin)FDA Link 01/2018 - 03/2009
6	Clarithromycin (Biaxin)FDA LinkGeneric 12/2005 - 05/2002
5	carbapenemaseIBA 01/2022 - 01/2014
5	Serine (L-Serine)FDA Link 12/2021 - 01/2019
5	tedizolidIBA 01/2019 - 05/2012
5	oritavancinIBA 10/2016 - 01/2005
5	FluoroquinolonesIBA 06/2016 - 04/2004
5	beta-Lactamases (beta-Lactamase)IBA 01/2008 - 03/2003
4	SiderophoresIBA 01/2022 - 02/2018
4	Penicillins (Penicillin)FDA Link 11/2021 - 04/2004
4	plazomicinIBA 10/2019 - 01/2018
4	dalbavancinIBA 10/2016 - 01/2005
4	Imipenem Drug Combination Cilastatin (Primaxin)FDA Link 02/2008 - 01/2005
3	Minocycline (Cyclops)FDA LinkGeneric 01/2022 - 05/2009
3	Ceftibuten (Cedax)FDA Link 02/2021 - 01/2019
3	nacubactamIBA 02/2020 - 01/2018
3	Piperacillin FDA LinkGeneric 01/2019 - 05/2002
3	LipoglycopeptidesIBA 10/2016 - 03/2007
3	Ciprofloxacin (Cipro)FDA LinkGeneric 08/2015 - 12/2005
3	Aztreonam FDA LinkGeneric 01/2014 - 02/2008
3	Gentamicins (Gentamicin)FDA LinkGeneric 01/2008 - 03/2004
3	Cantharidin (Cantharides)IBA 09/2007 - 05/2003

Therapy/Procedure

57	Therapeutics 01/2022 - 05/2002
10	Length of Stay 01/2018 - 06/2004
9	Catheters 01/2022 - 05/2007
6	Mechanical Ventilators (Ventilator) 01/2020 - 09/2011
4	Continuous Renal Replacement Therapy 07/2021 - 12/2015
3	Renal Dialysis (Hemodialysis) 06/2021 - 11/2011
3	Drug Therapy (Chemotherapy) 01/2018 - 01/2005
3	Critical Care (Surgical Intensive Care) 01/2017 - 02/2009